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Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG

Identifieur interne : 005708 ( Main/Exploration ); précédent : 005707; suivant : 005709

Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG

Auteurs : Lingyi Lu [États-Unis] ; Geraldine Cancel-Tassin [France] ; Antoine Valeri [France] ; Olivier Cussenot [France] ; Ethan M. Lange [États-Unis] ; Kathleen A. Cooney [États-Unis] ; James M. Farnham [États-Unis] ; Nicola J. Camp [États-Unis] ; Lisa A. Cannon-Albright [États-Unis] ; Teuvo L. J. Tammela [Finlande] ; Johanna Schleutker [Finlande] ; Josef Hoegel [Allemagne] ; Kathleen Herkommer [Allemagne] ; Christiane Maier [Allemagne] ; Walther Vogel [Allemagne] ; Fredrik Wiklund [Suède] ; Monica Emanuelsson [Suède] ; Henrik Grönberg [Suède] ; Kathleen E. Wiley [États-Unis] ; Sarah D. Isaacs [États-Unis] ; Patrick C. Walsh [États-Unis] ; Brian T. Helfand [États-Unis] ; Donghui Kan [États-Unis] ; William J. Catalona [États-Unis] ; Janet L. Stanford [États-Unis] ; Liesel M. Fitzgerald [États-Unis] ; Bo Johanneson [États-Unis] ; Kerry Deutsch [États-Unis] ; Laura Mcintosh [États-Unis] ; Elaine A. Ostrander [États-Unis] ; Stephen N. Thibodeau [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Scott Hebbring [États-Unis] ; Daniel J. Schaid [États-Unis] ; Alice S. Whittemore [États-Unis] ; Ingrid Oakley-Girvan [États-Unis] ; Chih-Lin Hsieh [États-Unis] ; Isaac Powell [États-Unis] ; Joan E. Bailey-Wilson [Finlande, États-Unis] ; Cheryl D. Cropp [Finlande, États-Unis] ; Claire Simpson [Finlande, États-Unis] ; John D. Carpten [États-Unis] ; Daniela Seminara [États-Unis] ; S. Lilly Zheng [États-Unis] ; Jianfen Xu [États-Unis] ; Graham G. Giles [Australie] ; Gianluca Severi [Australie] ; John L. Hopper [Australie] ; Dallas R. English [Australie] ; William D. Foulkes [Canada] ; Lovise Maehle [Norvège] ; Pal Moller [Norvège] ; Michael D. Badzioch [États-Unis] ; Steve Edwards [Royaume-Uni] ; Michelle Guy [Royaume-Uni] ; Ros Eeles [Royaume-Uni] ; Douglas Easton [Royaume-Uni] ; William B. Isaacs [États-Unis]

Source :

RBID : ISTEX:C8A729A8540526D1EDCC4BE3CF46CC06ABDCC676

Descripteurs français

English descriptors

Abstract

In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite‐based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members.

Url:
DOI: 10.1002/pros.21443


Affiliations:


Links toward previous steps (curation, corpus...)


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<name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name>
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<affiliation wicri:level="4">
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<wicri:regionArea>Institut fuer Humangenetik, Universität Ulm, Ulm</wicri:regionArea>
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<settlement type="city">Ulm</settlement>
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<orgName type="university">Université d'Ulm</orgName>
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<affiliation wicri:level="4">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Urologische Klinik, Universität Ulm, Ulm</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
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<orgName type="university">Université d'Ulm</orgName>
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<author>
<name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name>
<affiliation></affiliation>
<affiliation wicri:level="4">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut fuer Humangenetik, Universität Ulm, Ulm</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
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<orgName type="university">Université d'Ulm</orgName>
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<author>
<name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name>
<affiliation></affiliation>
<affiliation wicri:level="3">
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
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<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
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<author>
<name sortKey="Emanuelsson, Monica" sort="Emanuelsson, Monica" uniqKey="Emanuelsson M" first="Monica" last="Emanuelsson">Monica Emanuelsson</name>
<affiliation></affiliation>
<affiliation wicri:level="1">
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Oncologic Centre, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name>
<affiliation></affiliation>
<affiliation wicri:level="3">
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
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<author>
<name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Helfand, Brian T" sort="Helfand, Brian T" uniqKey="Helfand B" first="Brian T." last="Helfand">Brian T. Helfand</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Kan, Donghui" sort="Kan, Donghui" uniqKey="Kan D" first="Donghui" last="Kan">Donghui Kan</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Johanneson, Bo" sort="Johanneson, Bo" uniqKey="Johanneson B" first="Bo" last="Johanneson">Bo Johanneson</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Deutsch, Kerry" sort="Deutsch, Kerry" uniqKey="Deutsch K" first="Kerry" last="Deutsch">Kerry Deutsch</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Institute for Systems Biology, Seattle</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Mcintosh, Laura" sort="Mcintosh, Laura" uniqKey="Mcintosh L" first="Laura" last="Mcintosh">Laura Mcintosh</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Hebbring, Scott" sort="Hebbring, Scott" uniqKey="Hebbring S" first="Scott" last="Hebbring">Scott Hebbring</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Health Research and Policy, Stanford School of Medicine, Stanford</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Oakley Irvan, Ingrid" sort="Oakley Irvan, Ingrid" uniqKey="Oakley Irvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Hsieh, Chih In" sort="Hsieh, Chih In" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Powell, Isaac" sort="Powell, Isaac" uniqKey="Powell I" first="Isaac" last="Powell">Isaac Powell</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Karmanos Cancer Institute, Wayne State University, Detroit</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Bailey Ilson, Joan E" sort="Bailey Ilson, Joan E" uniqKey="Bailey Ilson J" first="Joan E." last="Bailey-Wilson">Joan E. Bailey-Wilson</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Human Genome Research Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Cropp, Cheryl D" sort="Cropp, Cheryl D" uniqKey="Cropp C" first="Cheryl D." last="Cropp">Cheryl D. Cropp</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Human Genome Research Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Simpson, Claire" sort="Simpson, Claire" uniqKey="Simpson C" first="Claire" last="Simpson">Claire Simpson</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Human Genome Research Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Carpten, John D" sort="Carpten, John D" uniqKey="Carpten J" first="John D." last="Carpten">John D. Carpten</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Genetic Basis of Human Disease Research Division, Translational Genomics Research Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Cancer Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston‐Salem</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Xu, Jianfen" sort="Xu, Jianfen" uniqKey="Xu J" first="Jianfen" last="Xu">Jianfen Xu</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston‐Salem</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation></affiliation>
<affiliation wicri:level="3">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation></affiliation>
<affiliation wicri:level="3">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation></affiliation>
<affiliation wicri:level="4">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author>
<name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name>
<affiliation></affiliation>
<affiliation wicri:level="4">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author>
<name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name>
<affiliation></affiliation>
<affiliation wicri:level="4">
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Cancer Genetics, McGill University, Montreal, Quebec</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName>
<settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maehle, Lovise" sort="Maehle, Lovise" uniqKey="Maehle L" first="Lovise" last="Maehle">Lovise Maehle</name>
<affiliation></affiliation>
<affiliation wicri:level="3">
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>The Norwegian Radium Hospital, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Moller, Pal" sort="Moller, Pal" uniqKey="Moller P" first="Pal" last="Moller">Pal Moller</name>
<affiliation></affiliation>
<affiliation wicri:level="3">
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>The Norwegian Radium Hospital, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Badzioch, Michael D" sort="Badzioch, Michael D" uniqKey="Badzioch M" first="Michael D." last="Badzioch">Michael D. Badzioch</name>
<affiliation></affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Division of Medical Genetics, University of Washington Medical Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Edwards, Steve" sort="Edwards, Steve" uniqKey="Edwards S" first="Steve" last="Edwards">Steve Edwards</name>
<affiliation></affiliation>
<affiliation wicri:level="1">
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey</wicri:regionArea>
<wicri:noRegion>Surrey</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name>
<affiliation></affiliation>
<affiliation wicri:level="1">
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey</wicri:regionArea>
<wicri:noRegion>Surrey</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation></affiliation>
<affiliation wicri:level="1">
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey</wicri:regionArea>
<wicri:noRegion>Surrey</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name>
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<affiliation wicri:level="1">
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
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</author>
<author>
<name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
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<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
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<affiliation wicri:level="1">
<country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Correspondence address: Marburg 115, Johns Hopkins Hospital, Baltimore</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j" type="main">The Prostate</title>
<title level="j" type="alt">PROSTATE, THE</title>
<idno type="ISSN">0270-4137</idno>
<idno type="eISSN">1097-0045</idno>
<imprint>
<biblScope unit="vol">72</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="410">410</biblScope>
<biblScope unit="page" to="426">426</biblScope>
<biblScope unit="page-count">17</biblScope>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2012-03">2012-03</date>
</imprint>
<idno type="ISSN">0270-4137</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0270-4137</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Actane group</term>
<term>Additional support</term>
<term>Aggressive disease</term>
<term>Allele</term>
<term>Association studies</term>
<term>Broad region</term>
<term>Cancer</term>
<term>Cancer cell</term>
<term>Cancer research</term>
<term>Caucasian families</term>
<term>Chromosome</term>
<term>Consortium</term>
<term>Epidemiology</term>
<term>Familial prostate cancer</term>
<term>Family collections</term>
<term>Family members</term>
<term>Family subset</term>
<term>Fred hutchinson cancer research center</term>
<term>Further analysis</term>
<term>Genes chromosomes cancer</term>
<term>Genet</term>
<term>Genetics</term>
<term>Genome</term>
<term>Genome research institute</term>
<term>Genomewide linkage analysis</term>
<term>Grant number</term>
<term>Hereditary prostate cancer</term>
<term>Hlod</term>
<term>Hlod scores</term>
<term>Human prostate carcinogenesis</term>
<term>Human prostatic carcinoma</term>
<term>Icpcg</term>
<term>Icpcg groups</term>
<term>International consortium</term>
<term>Large number</term>
<term>Largest family collections</term>
<term>Linkage</term>
<term>Linkage analysis</term>
<term>Linkage models</term>
<term>Linkage results</term>
<term>Linkage scan</term>
<term>Linkage scans</term>
<term>Linkage signals</term>
<term>Locus</term>
<term>Mcgill university</term>
<term>Medical genetics</term>
<term>Medical records</term>
<term>Merlin software</term>
<term>Microsatellite markers</term>
<term>Multiple loci</term>
<term>National institutes</term>
<term>Other regions</term>
<term>Previous scan</term>
<term>Previous studies</term>
<term>Proc natl acad</term>
<term>Prostate</term>
<term>Prostate cancer</term>
<term>Prostate cancer genetics</term>
<term>Prostate cancer susceptibility</term>
<term>Prostate cancer susceptibility loci</term>
<term>Recessive model</term>
<term>Risk alleles</term>
<term>Scan</term>
<term>Strongest linkage signals</term>
<term>Subset</term>
<term>Suggestive evidence</term>
<term>Suggestive linkage</term>
<term>Susceptibility</term>
<term>Susceptibility loci</term>
<term>Systematic review</term>
<term>Univ</term>
<term>Usphs</term>
<term>Wiley periodicals</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Actane group</term>
<term>Additional support</term>
<term>Aggressive disease</term>
<term>Allele</term>
<term>Association studies</term>
<term>Broad region</term>
<term>Cancer</term>
<term>Cancer cell</term>
<term>Cancer research</term>
<term>Caucasian families</term>
<term>Chromosome</term>
<term>Consortium</term>
<term>Epidemiology</term>
<term>Familial prostate cancer</term>
<term>Family collections</term>
<term>Family members</term>
<term>Family subset</term>
<term>Fred hutchinson cancer research center</term>
<term>Further analysis</term>
<term>Genes chromosomes cancer</term>
<term>Genet</term>
<term>Genetics</term>
<term>Genome</term>
<term>Genome research institute</term>
<term>Genomewide linkage analysis</term>
<term>Grant number</term>
<term>Hereditary prostate cancer</term>
<term>Hlod</term>
<term>Hlod scores</term>
<term>Human prostate carcinogenesis</term>
<term>Human prostatic carcinoma</term>
<term>Icpcg</term>
<term>Icpcg groups</term>
<term>International consortium</term>
<term>Large number</term>
<term>Largest family collections</term>
<term>Linkage</term>
<term>Linkage analysis</term>
<term>Linkage models</term>
<term>Linkage results</term>
<term>Linkage scan</term>
<term>Linkage scans</term>
<term>Linkage signals</term>
<term>Locus</term>
<term>Mcgill university</term>
<term>Medical genetics</term>
<term>Medical records</term>
<term>Merlin software</term>
<term>Microsatellite markers</term>
<term>Multiple loci</term>
<term>National institutes</term>
<term>Other regions</term>
<term>Previous scan</term>
<term>Previous studies</term>
<term>Proc natl acad</term>
<term>Prostate</term>
<term>Prostate cancer</term>
<term>Prostate cancer genetics</term>
<term>Prostate cancer susceptibility</term>
<term>Prostate cancer susceptibility loci</term>
<term>Recessive model</term>
<term>Risk alleles</term>
<term>Scan</term>
<term>Strongest linkage signals</term>
<term>Subset</term>
<term>Suggestive evidence</term>
<term>Suggestive linkage</term>
<term>Susceptibility</term>
<term>Susceptibility loci</term>
<term>Systematic review</term>
<term>Univ</term>
<term>Usphs</term>
<term>Wiley periodicals</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Cancer</term>
<term>Consortium</term>
<term>épidémiologie</term>
<term>Génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract">In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite‐based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Finlande</li>
<li>France</li>
<li>Norvège</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region>
<li>Arizona</li>
<li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>District de Haute-Bavière</li>
<li>District de Tübingen</li>
<li>Illinois</li>
<li>Maryland</li>
<li>Michigan</li>
<li>Minnesota</li>
<li>Québec</li>
<li>Svealand</li>
<li>Utah</li>
<li>Victoria (État)</li>
<li>Washington (État)</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement>
<li>Melbourne</li>
<li>Montréal</li>
<li>Munich</li>
<li>Oslo</li>
<li>Paris</li>
<li>Stockholm</li>
<li>Ulm</li>
</settlement>
<orgName>
<li>Université McGill</li>
<li>Université d'Ulm</li>
<li>Université de Melbourne</li>
</orgName>
</list>
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<name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name>
<name sortKey="Cropp, Cheryl D" sort="Cropp, Cheryl D" uniqKey="Cropp C" first="Cheryl D." last="Cropp">Cheryl D. Cropp</name>
<name sortKey="Deutsch, Kerry" sort="Deutsch, Kerry" uniqKey="Deutsch K" first="Kerry" last="Deutsch">Kerry Deutsch</name>
<name sortKey="Farnham, James M" sort="Farnham, James M" uniqKey="Farnham J" first="James M." last="Farnham">James M. Farnham</name>
<name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name>
<name sortKey="Hebbring, Scott" sort="Hebbring, Scott" uniqKey="Hebbring S" first="Scott" last="Hebbring">Scott Hebbring</name>
<name sortKey="Helfand, Brian T" sort="Helfand, Brian T" uniqKey="Helfand B" first="Brian T." last="Helfand">Brian T. Helfand</name>
<name sortKey="Hsieh, Chih In" sort="Hsieh, Chih In" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name>
<name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name>
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