Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG
Identifieur interne : 005708 ( Main/Exploration ); précédent : 005707; suivant : 005709Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG
Auteurs : Lingyi Lu [États-Unis] ; Geraldine Cancel-Tassin [France] ; Antoine Valeri [France] ; Olivier Cussenot [France] ; Ethan M. Lange [États-Unis] ; Kathleen A. Cooney [États-Unis] ; James M. Farnham [États-Unis] ; Nicola J. Camp [États-Unis] ; Lisa A. Cannon-Albright [États-Unis] ; Teuvo L. J. Tammela [Finlande] ; Johanna Schleutker [Finlande] ; Josef Hoegel [Allemagne] ; Kathleen Herkommer [Allemagne] ; Christiane Maier [Allemagne] ; Walther Vogel [Allemagne] ; Fredrik Wiklund [Suède] ; Monica Emanuelsson [Suède] ; Henrik Grönberg [Suède] ; Kathleen E. Wiley [États-Unis] ; Sarah D. Isaacs [États-Unis] ; Patrick C. Walsh [États-Unis] ; Brian T. Helfand [États-Unis] ; Donghui Kan [États-Unis] ; William J. Catalona [États-Unis] ; Janet L. Stanford [États-Unis] ; Liesel M. Fitzgerald [États-Unis] ; Bo Johanneson [États-Unis] ; Kerry Deutsch [États-Unis] ; Laura Mcintosh [États-Unis] ; Elaine A. Ostrander [États-Unis] ; Stephen N. Thibodeau [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Scott Hebbring [États-Unis] ; Daniel J. Schaid [États-Unis] ; Alice S. Whittemore [États-Unis] ; Ingrid Oakley-Girvan [États-Unis] ; Chih-Lin Hsieh [États-Unis] ; Isaac Powell [États-Unis] ; Joan E. Bailey-Wilson [Finlande, États-Unis] ; Cheryl D. Cropp [Finlande, États-Unis] ; Claire Simpson [Finlande, États-Unis] ; John D. Carpten [États-Unis] ; Daniela Seminara [États-Unis] ; S. Lilly Zheng [États-Unis] ; Jianfen Xu [États-Unis] ; Graham G. Giles [Australie] ; Gianluca Severi [Australie] ; John L. Hopper [Australie] ; Dallas R. English [Australie] ; William D. Foulkes [Canada] ; Lovise Maehle [Norvège] ; Pal Moller [Norvège] ; Michael D. Badzioch [États-Unis] ; Steve Edwards [Royaume-Uni] ; Michelle Guy [Royaume-Uni] ; Ros Eeles [Royaume-Uni] ; Douglas Easton [Royaume-Uni] ; William B. Isaacs [États-Unis]Source :
- The Prostate [ 0270-4137 ] ; 2012-03.
Descripteurs français
- Wicri :
- topic : Cancer, Consortium, épidémiologie, Génétique.
English descriptors
- KwdEn :
- Actane group, Additional support, Aggressive disease, Allele, Association studies, Broad region, Cancer, Cancer cell, Cancer research, Caucasian families, Chromosome, Consortium, Epidemiology, Familial prostate cancer, Family collections, Family members, Family subset, Fred hutchinson cancer research center, Further analysis, Genes chromosomes cancer, Genet, Genetics, Genome, Genome research institute, Genomewide linkage analysis, Grant number, Hereditary prostate cancer, Hlod, Hlod scores, Human prostate carcinogenesis, Human prostatic carcinoma, Icpcg, Icpcg groups, International consortium, Large number, Largest family collections, Linkage, Linkage analysis, Linkage models, Linkage results, Linkage scan, Linkage scans, Linkage signals, Locus, Mcgill university, Medical genetics, Medical records, Merlin software, Microsatellite markers, Multiple loci, National institutes, Other regions, Previous scan, Previous studies, Proc natl acad, Prostate, Prostate cancer, Prostate cancer genetics, Prostate cancer susceptibility, Prostate cancer susceptibility loci, Recessive model, Risk alleles, Scan, Strongest linkage signals, Subset, Suggestive evidence, Suggestive linkage, Susceptibility, Susceptibility loci, Systematic review, Univ, Usphs, Wiley periodicals.
- Teeft :
- Actane group, Additional support, Aggressive disease, Allele, Association studies, Broad region, Cancer, Cancer cell, Cancer research, Caucasian families, Chromosome, Consortium, Epidemiology, Familial prostate cancer, Family collections, Family members, Family subset, Fred hutchinson cancer research center, Further analysis, Genes chromosomes cancer, Genet, Genetics, Genome, Genome research institute, Genomewide linkage analysis, Grant number, Hereditary prostate cancer, Hlod, Hlod scores, Human prostate carcinogenesis, Human prostatic carcinoma, Icpcg, Icpcg groups, International consortium, Large number, Largest family collections, Linkage, Linkage analysis, Linkage models, Linkage results, Linkage scan, Linkage scans, Linkage signals, Locus, Mcgill university, Medical genetics, Medical records, Merlin software, Microsatellite markers, Multiple loci, National institutes, Other regions, Previous scan, Previous studies, Proc natl acad, Prostate, Prostate cancer, Prostate cancer genetics, Prostate cancer susceptibility, Prostate cancer susceptibility loci, Recessive model, Risk alleles, Scan, Strongest linkage signals, Subset, Suggestive evidence, Suggestive linkage, Susceptibility, Susceptibility loci, Systematic review, Univ, Usphs, Wiley periodicals.
Abstract
In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite‐based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members.
Url:
- https://api.istex.fr/document/C8A729A8540526D1EDCC4BE3CF46CC06ABDCC676/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568777
DOI: 10.1002/pros.21443
Affiliations:
- Allemagne, Australie, Canada, Finlande, France, Norvège, Royaume-Uni, Suède, États-Unis
- Arizona, Bade-Wurtemberg, Bavière, Californie, Caroline du Nord, District de Haute-Bavière, District de Tübingen, Illinois, Maryland, Michigan, Minnesota, Québec, Svealand, Utah, Victoria (État), Washington (État), Île-de-France, Østlandet
- Melbourne, Montréal, Munich, Oslo, Paris, Stockholm, Ulm
- Université McGill, Université d'Ulm, Université de Melbourne
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<author><name sortKey="Hoegel, Josef" sort="Hoegel, Josef" uniqKey="Hoegel J" first="Josef" last="Hoegel">Josef Hoegel</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut fuer Humangenetik, Universität Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Herkommer, Kathleen" sort="Herkommer, Kathleen" uniqKey="Herkommer K" first="Kathleen" last="Herkommer">Kathleen Herkommer</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Urologische Klinik, Universität Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Urologische Klinik rechts der Isar, Technische Universitaet Muenchen, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut fuer Humangenetik, Universität Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Urologische Klinik, Universität Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut fuer Humangenetik, Universität Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name>
<affiliation></affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Emanuelsson, Monica" sort="Emanuelsson, Monica" uniqKey="Emanuelsson M" first="Monica" last="Emanuelsson">Monica Emanuelsson</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Oncologic Centre, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name>
<affiliation></affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Helfand, Brian T" sort="Helfand, Brian T" uniqKey="Helfand B" first="Brian T." last="Helfand">Brian T. Helfand</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kan, Donghui" sort="Kan, Donghui" uniqKey="Kan D" first="Donghui" last="Kan">Donghui Kan</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University ICPCG Group, Department of Urology, Northwestern University Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Johanneson, Bo" sort="Johanneson, Bo" uniqKey="Johanneson B" first="Bo" last="Johanneson">Bo Johanneson</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Deutsch, Kerry" sort="Deutsch, Kerry" uniqKey="Deutsch K" first="Kerry" last="Deutsch">Kerry Deutsch</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Institute for Systems Biology, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mcintosh, Laura" sort="Mcintosh, Laura" uniqKey="Mcintosh L" first="Laura" last="Mcintosh">Laura Mcintosh</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hebbring, Scott" sort="Hebbring, Scott" uniqKey="Hebbring S" first="Scott" last="Hebbring">Scott Hebbring</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic ICPCG Group, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Health Research and Policy, Stanford School of Medicine, Stanford</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Oakley Irvan, Ingrid" sort="Oakley Irvan, Ingrid" uniqKey="Oakley Irvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hsieh, Chih In" sort="Hsieh, Chih In" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Powell, Isaac" sort="Powell, Isaac" uniqKey="Powell I" first="Isaac" last="Powell">Isaac Powell</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Karmanos Cancer Institute, Wayne State University, Detroit</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bailey Ilson, Joan E" sort="Bailey Ilson, Joan E" uniqKey="Bailey Ilson J" first="Joan E." last="Bailey-Wilson">Joan E. Bailey-Wilson</name>
<affiliation wicri:level="1"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Human Genome Research Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cropp, Cheryl D" sort="Cropp, Cheryl D" uniqKey="Cropp C" first="Cheryl D." last="Cropp">Cheryl D. Cropp</name>
<affiliation wicri:level="1"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Human Genome Research Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simpson, Claire" sort="Simpson, Claire" uniqKey="Simpson C" first="Claire" last="Simpson">Claire Simpson</name>
<affiliation wicri:level="1"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Tampere ICPCG Group, Institute of Biomedical Technology, University of Tampere and Centre for Laboratory Medicine, Tampere University Hospital, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Human Genome Research Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Carpten, John D" sort="Carpten, John D" uniqKey="Carpten J" first="John D." last="Carpten">John D. Carpten</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Genetic Basis of Human Disease Research Division, Translational Genomics Research Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Cancer Institute, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston‐Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Xu, Jianfen" sort="Xu, Jianfen" uniqKey="Xu J" first="Jianfen" last="Xu">Jianfen Xu</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston‐Salem</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation></affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation></affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Cancer Genetics, McGill University, Montreal, Quebec</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maehle, Lovise" sort="Maehle, Lovise" uniqKey="Maehle L" first="Lovise" last="Maehle">Lovise Maehle</name>
<affiliation></affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>The Norwegian Radium Hospital, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moller, Pal" sort="Moller, Pal" uniqKey="Moller P" first="Pal" last="Moller">Pal Moller</name>
<affiliation></affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>The Norwegian Radium Hospital, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Badzioch, Michael D" sort="Badzioch, Michael D" uniqKey="Badzioch M" first="Michael D." last="Badzioch">Michael D. Badzioch</name>
<affiliation></affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Division of Medical Genetics, University of Washington Medical Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Edwards, Steve" sort="Edwards, Steve" uniqKey="Edwards S" first="Steve" last="Edwards">Steve Edwards</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey</wicri:regionArea>
<wicri:noRegion>Surrey</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey</wicri:regionArea>
<wicri:noRegion>Surrey</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey</wicri:regionArea>
<wicri:noRegion>Surrey</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Correspondence address: Marburg 115, Johns Hopkins Hospital, Baltimore</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The Prostate</title>
<title level="j" type="alt">PROSTATE, THE</title>
<idno type="ISSN">0270-4137</idno>
<idno type="eISSN">1097-0045</idno>
<imprint><biblScope unit="vol">72</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="410">410</biblScope>
<biblScope unit="page" to="426">426</biblScope>
<biblScope unit="page-count">17</biblScope>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2012-03">2012-03</date>
</imprint>
<idno type="ISSN">0270-4137</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0270-4137</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actane group</term>
<term>Additional support</term>
<term>Aggressive disease</term>
<term>Allele</term>
<term>Association studies</term>
<term>Broad region</term>
<term>Cancer</term>
<term>Cancer cell</term>
<term>Cancer research</term>
<term>Caucasian families</term>
<term>Chromosome</term>
<term>Consortium</term>
<term>Epidemiology</term>
<term>Familial prostate cancer</term>
<term>Family collections</term>
<term>Family members</term>
<term>Family subset</term>
<term>Fred hutchinson cancer research center</term>
<term>Further analysis</term>
<term>Genes chromosomes cancer</term>
<term>Genet</term>
<term>Genetics</term>
<term>Genome</term>
<term>Genome research institute</term>
<term>Genomewide linkage analysis</term>
<term>Grant number</term>
<term>Hereditary prostate cancer</term>
<term>Hlod</term>
<term>Hlod scores</term>
<term>Human prostate carcinogenesis</term>
<term>Human prostatic carcinoma</term>
<term>Icpcg</term>
<term>Icpcg groups</term>
<term>International consortium</term>
<term>Large number</term>
<term>Largest family collections</term>
<term>Linkage</term>
<term>Linkage analysis</term>
<term>Linkage models</term>
<term>Linkage results</term>
<term>Linkage scan</term>
<term>Linkage scans</term>
<term>Linkage signals</term>
<term>Locus</term>
<term>Mcgill university</term>
<term>Medical genetics</term>
<term>Medical records</term>
<term>Merlin software</term>
<term>Microsatellite markers</term>
<term>Multiple loci</term>
<term>National institutes</term>
<term>Other regions</term>
<term>Previous scan</term>
<term>Previous studies</term>
<term>Proc natl acad</term>
<term>Prostate</term>
<term>Prostate cancer</term>
<term>Prostate cancer genetics</term>
<term>Prostate cancer susceptibility</term>
<term>Prostate cancer susceptibility loci</term>
<term>Recessive model</term>
<term>Risk alleles</term>
<term>Scan</term>
<term>Strongest linkage signals</term>
<term>Subset</term>
<term>Suggestive evidence</term>
<term>Suggestive linkage</term>
<term>Susceptibility</term>
<term>Susceptibility loci</term>
<term>Systematic review</term>
<term>Univ</term>
<term>Usphs</term>
<term>Wiley periodicals</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Actane group</term>
<term>Additional support</term>
<term>Aggressive disease</term>
<term>Allele</term>
<term>Association studies</term>
<term>Broad region</term>
<term>Cancer</term>
<term>Cancer cell</term>
<term>Cancer research</term>
<term>Caucasian families</term>
<term>Chromosome</term>
<term>Consortium</term>
<term>Epidemiology</term>
<term>Familial prostate cancer</term>
<term>Family collections</term>
<term>Family members</term>
<term>Family subset</term>
<term>Fred hutchinson cancer research center</term>
<term>Further analysis</term>
<term>Genes chromosomes cancer</term>
<term>Genet</term>
<term>Genetics</term>
<term>Genome</term>
<term>Genome research institute</term>
<term>Genomewide linkage analysis</term>
<term>Grant number</term>
<term>Hereditary prostate cancer</term>
<term>Hlod</term>
<term>Hlod scores</term>
<term>Human prostate carcinogenesis</term>
<term>Human prostatic carcinoma</term>
<term>Icpcg</term>
<term>Icpcg groups</term>
<term>International consortium</term>
<term>Large number</term>
<term>Largest family collections</term>
<term>Linkage</term>
<term>Linkage analysis</term>
<term>Linkage models</term>
<term>Linkage results</term>
<term>Linkage scan</term>
<term>Linkage scans</term>
<term>Linkage signals</term>
<term>Locus</term>
<term>Mcgill university</term>
<term>Medical genetics</term>
<term>Medical records</term>
<term>Merlin software</term>
<term>Microsatellite markers</term>
<term>Multiple loci</term>
<term>National institutes</term>
<term>Other regions</term>
<term>Previous scan</term>
<term>Previous studies</term>
<term>Proc natl acad</term>
<term>Prostate</term>
<term>Prostate cancer</term>
<term>Prostate cancer genetics</term>
<term>Prostate cancer susceptibility</term>
<term>Prostate cancer susceptibility loci</term>
<term>Recessive model</term>
<term>Risk alleles</term>
<term>Scan</term>
<term>Strongest linkage signals</term>
<term>Subset</term>
<term>Suggestive evidence</term>
<term>Suggestive linkage</term>
<term>Susceptibility</term>
<term>Susceptibility loci</term>
<term>Systematic review</term>
<term>Univ</term>
<term>Usphs</term>
<term>Wiley periodicals</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cancer</term>
<term>Consortium</term>
<term>épidémiologie</term>
<term>Génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite‐based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Finlande</li>
<li>France</li>
<li>Norvège</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>District de Haute-Bavière</li>
<li>District de Tübingen</li>
<li>Illinois</li>
<li>Maryland</li>
<li>Michigan</li>
<li>Minnesota</li>
<li>Québec</li>
<li>Svealand</li>
<li>Utah</li>
<li>Victoria (État)</li>
<li>Washington (État)</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement><li>Melbourne</li>
<li>Montréal</li>
<li>Munich</li>
<li>Oslo</li>
<li>Paris</li>
<li>Stockholm</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université d'Ulm</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Lu, Lingyi" sort="Lu, Lingyi" uniqKey="Lu L" first="Lingyi" last="Lu">Lingyi Lu</name>
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<name sortKey="Carpten, John D" sort="Carpten, John D" uniqKey="Carpten J" first="John D." last="Carpten">John D. Carpten</name>
<name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name>
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<name sortKey="Cropp, Cheryl D" sort="Cropp, Cheryl D" uniqKey="Cropp C" first="Cheryl D." last="Cropp">Cheryl D. Cropp</name>
<name sortKey="Deutsch, Kerry" sort="Deutsch, Kerry" uniqKey="Deutsch K" first="Kerry" last="Deutsch">Kerry Deutsch</name>
<name sortKey="Farnham, James M" sort="Farnham, James M" uniqKey="Farnham J" first="James M." last="Farnham">James M. Farnham</name>
<name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name>
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<name sortKey="Helfand, Brian T" sort="Helfand, Brian T" uniqKey="Helfand B" first="Brian T." last="Helfand">Brian T. Helfand</name>
<name sortKey="Hsieh, Chih In" sort="Hsieh, Chih In" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name>
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<name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
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<name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name>
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<name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name>
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<name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name>
</country>
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<name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name>
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